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updated July 25th 2019

  1. Furlan, I.; Domljanovic, I.; Uhd, J.; (2019) Improving design of synthetic oligonucleotide probes by fluorescence melting assay. 20, 587-594.

  2. Khatri, S.; Torok, K.; Astakhova, K. Autoantibodies in morphea - An update (2019). Front Immunol. https://doi.org/10.3389/fimmu.2019.01487

  3. Astakhova, K.; Ray R, Taskova M.; Uhd, J.; Carstens, A.; Morris, K. “Clicking” Gene Therapeutics: A Successful Union of Chemistry and Biomedicine for New Solutions (2018). , mp7b00765.

  4. Domljanovic, I.; Taskova, M.; . Studies of impending oligonucleotide therapeutics in simulated biofluids. Nucleic Acid Ther. 2018, 28, 348-356.

  5. Klecka, Martin; Thybo, Christina ; Macaubas, Claudia ; Solov'yov, Ilia ; Simard, Julia ; Balboni, I. M.; Fox, E.; Voss, Anne ; Mellins, Elizabeth D ; Astakhova, Kira. Autoantibody Profiling in Lupus Patients using Synthetic Nucleic Acids. Sci. Rep. 2018, 8, DOI: http://dx.doi.org/10.1038/s41598-018-23910-5

  6. Samuelsen, S.; Jørgensen, C. D.; Mellins, E. D.; Torok, K. S., (2018) Detection of autoimmune antibodies in localized scleroderma by synthetic oligonucleotide antigens. 13(4): e0195381.

  7. Domljanovic, Ivana ; Rexen Ulven, Elisabeth ; Ulven, Trond ; Thomsen, Rasmus P.; Okholm, Anders H. ; Kjems, Jørgen ; Voss, Anne ; Taskova, Maria ; Astakhova, Kira (2018) Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum. ACS Omega, 3, 7580-7586.

  8. Taskova, M.; Uhd, J.; Miotke, L.; Kubit, M.; Bell, J.; Ji, H. P.; . Tandem Oligonucleotide Probe Annealing and Elongation To Discriminate Viral Sequence. ., 2017, 89 (8), pp 4363–4366.

  9.  Domljanovic, I.; Carstens, A.; Okholm, A.; Kjems, J.; Nielsen, C. T.;Heegaard, N. H. H.; . Complexes of DNA with fluorescent dyes are effective reagents for detection of autoimmune antibodies 2017, 7, 1925.

  10. Astakhova, K.; Korshun, V. et al. 2'-O-Me RNA probes modified with pyrene fluorophores: Attachment point matters. Tetrahedron 2017, 73, 3220-3230.

  11. Taskova, M.; Mantsiou, A.; . Synthetic Nucleic Acid Analogues in Gene Therapy: An update for Peptide-Oligonucleotide Conjugates. 2017, DOI: 10.1002/cbic.201700229

  12. Taskova, M.; Barducci, M. C.; . Environmentally sensitive molecular probes reveal mutations and epigenetic 5-methyl cytosine in human oncogenes. 2017, 15, 5680-5684.

  13. Westergaard Mulberg, M.; Taskova, M.; Thomsen, R. P.; Okholm, A. H.; Kjems, J.; . New Fluorescent Nanoparticles for Ultrasensitive Detection of Nucleic Acids by Optical Methods. . 2017, doi: 10.1002/cbic.201700125.

  14. Samuelsen, S. V.; Maity, A.; Nybo, M.; Macaubas, C.; Lønstrup, L.; Balboni, I. M.; Mellins, E.; Novel Phospholipid-Protein Conjugates Allow Improved Detection of Antibodies in Patients with Autoimmune Diseases (2016). 11(6): e0156125.

  15. Junager, N.; Kongsted, J.; . Revealing Nucleic Acid Mutations Using Förster Resonance Energy Transfer-Based Probes (2016). 16, 1173.

  16. Samuelsen, S. V.; Solov'yov, I. A.; Balboni, I. M.; Mellins, E.; Nielsen, C. T.; Heegaard, N. H.; Synthetic oligonucleotide antigens modified with locked nucleic acids detect disease specific antibodies. . 2016; 6:35827.

  17. , M.; Madsen, C. S.; Jensen, K. J.;  Hansen, L. H.; Vester, B.; Astakhova, K. Antisense Oligonucleotides Internally Labeled with Peptides Show Improved Target Recognition and Stability to Enzymatic Degradation. Bioconjugate Chem. 2016, DOI: 10.1021/acs.bioconjchem.6b00567.

  18. Nåbo, L. J.; Madsen, C. S.; Jensen, K. J.; Kongsted, J.; . Ultramild protein-mediated click chemistry creates efficient oligonucleotide probes for targeting and detecting nucleic acids (2015). 16, 1163-1167.

  19. Maity, A.; Macaubas, C.; Mellins, E.; . Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies (2015). s 20, 10253-10263.

  20. Miotke, L.; Ji, H.P.; . Amplification-Free LNA/DNA Assay for Rapid Genotyping of Cancer DNA (2015). 10(8): e0136720.

  21. Astakhova, I. K.; Wengel, J. Scaffolding along nucleic acid duplexes using 2'-amino-locked nucleic acids. (2014). Acc. Chem. Res. 19, 1112–1122.

  22. Astakhova, K. Toward non-enzymatic ultrasensitive identification of single nucleotide polymorphisms by optical methods (2014). Chemosensors 2, 193-206.

  23. Okholm, A.; Kjems, J.; . Fluorescence detection of natural RNA using rationally designed “clickable” oligonucleotide probes (2014). 4, 45653-45656.

  24. Astakhova, I. K.; Hansen, L. H.; Vester, B.; Wengel, J. Peptide-LNA oligonucleotide conjugates (2013). Org. Biomol. Chem. 11, 4240–4249.

  25. Astakhova, I. K.; Wengel, J. Interfacing click chemistry with automated oligonucleotide synthesis for the preparation of fluorescent DNA probes containing internal xanthene and cyanine dyes (2013). Chem. Eur. J. 19, 1112–1122.

  26. Astakhova, I. K.; Kumar, T. S.; Campbell, M. A.; Ustinov, A. V.; Korshun, V. A.; Wengel, J. Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2'-α-L-amino-LNA FRET pairs (2013). Chem. Commun. 49, 511–513.

  27. Astakhova, I. K.; Pasternak, K.; Campbell, M. A.; Gupta, P.; Wengel, J. A locked nucleic acid-based nanocrawler: designed and reversible movement detected by multicolor fluorescence (2013). J. Am. Chem. Soc. 135, 2423–2426.

  28. Kumar, T. S.; Myznikova, A.; Samokhina, E.; Rapid Genotyping Using Pyrene−Perylene Locked Nucleic Acid Complexes (2013). 4, 58–68.

  29. Jørgensen, A. S.; Gupta, P.; Wengel, J.; “Clickable” LNA/DNA Probes for Fluorescence Sensing of Nucleic Acids and Autoimmune Antibodies (2013). . 49, 10751-10753.

  30. Astakhova, K. LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies (2013). Clin. Cell. Immunol. 4:5.

  31. Astakhova, I. K.; Samokhina, E.; Babu, B. R.; Wengel, J. Novel (phenylethynyl)pyrene-LNA constructs for fluorescence SNP sensing in polymorphic nucleic acid targets (2012). ChemBioChem 13, 1509–1519.

  32. Astakhova, I. V.; Usinov, A. V.; Korshun, V. A.; Wengel, J. LNA for optimization of fluorescent oligonucleotide probes: improved target binding and spectral properties (2011). Bioconjugate Chem. 22, 533–539.

  33. Astakhova, I. V.; Kumar, T. S.; Wengel, J. Fluorescent oligonucleotides containing a novel perylene 2′-amino-α-L-LNA: synthesis and analytical potential (2011). Collect. Chem. Commun. 76, 1347–1360

  34. Astakhova, I. V.; Lindegaard, D.; Malakhov, A. D.; Korshun, V. A.; Wengel, J. Novel interstrand communication systems based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2’-amino-LNA within DNA duplexes: high-affinity hybridization and fluorescence sensing (2010). Chem. Commun. 46, 8362–8364.

  35. Lindegaard, D.; Madsen, A. S.; ; Malakhov, A. D.; Babu, B. R.; Korshun, V. A.; Wengel, J. Pyrene–perylene as a FRET pair coupled to the N2′-functionality of 2′-amino-LNA (2008). 16, 94–99.

  36. Astakhova, I. V.; Korshun, V. A.; Wengel, J. Novel long-wave emission fluorochrome based upon perylen-3-ylcarbonyl-functionalized 2′-amino-LNA (2008). Chemistry of Nucleic Acid Components, 10, 307–308.

  37. Astakhova, I. V.; Korshun, V. A.; Wengel, J. (Phenylethynyl)pyrenes attached to 2′-amino-LNA: novel fluorescent dyes with the advantages of long-wave emission, high fluorescence quantum yields and excimer formation (2008). Chemistry of Nucleic Acid Components, 10, 491–495.

  38. Filichev, V. V.; ; Malakhov, A. D.; Korshun, V.A.; Pedersen, E. B. DNA glue: 1-, 2- and 4-ethynylpyrenes in the structure of twisted intercalating nucleic aids (TINAs), DNA duplexes/triplexes and interstrand excimer formation (2008). 52, 347–348.

  39. Filichev, V. V.; ; Malakhov, A. D.; Korshun, V. A.; Pedersen, E. B. 1-, 2- and 4-Ethynylpyrenes in the structure of twisted intercalating nucleic acids: structure, thermal stability, and fluorescence relationship (2008). 14, 9968–9980.

  40. Astakhova, I. V.; Korshun, V. A.; Jahn, K.; Kjems, J.; Wengel, J. Perylene attached to 2′-amino-LNA: synthesis, incorporation into oligonucleotides and remarkable fluorescence properties in vitro and in cell culture (2008). Bioconjugate Chem. 19, 1995–2007.

  41. Astakhova, I. V.; Korshun, V. A.; Wengel, J. Highly fluorescent conjugated pyrenes in nucleic acid probes: (phenylethynyl)pyrenecarbonyl-functionalized locked nucleic acid (2008). Chem. Eur. J. 14, 11010–11026.

  42. Ustinov, A. V.; Shmanai, V. V.; Patel, K.; Stepanova, I. A.; Prokhorenko, I. A.; ; Malakhov, A. D.; Skorobogatyi, M. V.; Bernad Jr, P. L.; Khan, S.; Shahgholi, M.; Southern, E. M.; Korshun, V. A.; Shchepinov, M. S. Reactive trityl derivatives: stabilised carbocation mass-tags for life sciences applications (2008). 6, 4593–4608.

  43. Astakhova, I. V.; Korshun, V. A. 2- and 4-Phenylethynylpyrenes, novel fluorescent labeles for DNA (2008). Russ. J. Bioorg. Chem. 34, 510–512.

  44. Astakhova, I. V.; Malakhov, A. D.; Stepanova, I. A.; Ustinov, A. V.; Bondarev, S. L.; Paramonov, A. S.; Korshun, V. A. 1-Phenylethynylpyrene (1-PEPy) as refined excimer forming alternative to pyrene: case of DNA major groove excimer (2007). Bioconjugate Chem. 18, 1972–1980.

  45. Pchelintseva, A. A.; Skorobogatyi, M. V.; Petrunina, A. L.; Andronova, V. L.; Galegov, G. A.; ; Ustinov, A. V.; Malakhov, A. D.; Korshun, V. A. Synthesis and evaluation of anti-HSV activity of new 5-alkynyl-2′-deoxyuridines (2005). 24, 923–926.

  46. Kryshtal, G. V.; Zhdankina, G. M.; ; Zlotin, S. G. Reactions of СН-acids with α,β-unsaturated aldehydes in ionic liquids (2004). 53, 647–651.

 

BOOK CHAPTERS

 

  1. Barducci, M. C.; Carstens, A.; Rexen, E.; Ulven, T.. “Signal-enhancing approaches and rational probe design enable amplification-free detection of nucleic acids” Advances in Sensors: Reviews, Vol. 5. 2019.

  2. Astakhova, K. Sensing of SNP in HIV-1 genome using fluorescent oligonucleotide probes (2015). Frontiers in Clinical Drug Research - HIV, Bentham Sciences, pp. 83-122.

  3. Astakhova, K.; Ji, H. P. Fluorescent Nucleic Acid Analogues in Research and Clinical Diagnostics (2015). RNA and DNA diagnostics, Springer Verlag, pp. 161-181.

  4. Prokhorenko, T. A.; ; Momynaliev, K. T.; Zatsepin, T. S.; Korshun, V. A. Phenylethynylpyrene Excimer Forming Hybridization Probes for Fluorescence SNP Detection. Methods in Molecular Biology, vol. 578, SpringerLink 2009, pp. 209.

  5. Kryshtal, G. V.; Zhdankina, G. M.; Shestopalov, А. А.; ; Evdokimova, G. V.; Shinkova, N. A.; Yfit, S. S.; Zlotin, S. G. Reactions of СН-acids and Polychloroorganic Compounds in Ionic Liquids. Green Chemistry in Russia, Eds. Lunin, V. V.; Tundo, P.; Lokteva, E. S. INCA, 2005, pp. 53.

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